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Protein Traps

Sandia researchers have produced a microfluidics device that can adsorb proteins from solution, hold them with negligible denaturation and release them on command (Science, July 18, 2003).
Sandia researchers have produced a microfluidics device that can adsorb proteins from solution, hold them with negligible denaturation and release them on command (Science, July 18, 2003).


The device consists of an array of gold or platinum heater lines on a thin, freestanding silicon nitride layer on a silicon frame - essentially a microfluidic hotplate. The active material is an end-tethered monolayer of poly(N-isopropylacrylamide) or PNIPAM. This polymer has a lower critical solution temperature (LCST) of 35C.


The result of this is that adsorption of large globular proteins is negligible at room temperature but above the LCST is extensive. This is the feature that traps the proteins.


The fluid volume on the device is 3microlitres confined over a working area of 2500x200microns. The heater lines can be 10, 20 or 50microns wide.



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