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ST Link For DNA Chip

STMicroelectronics has made a joint development agreement with MobiDiag to create a complete system for genomic-based detection of infectious diseases based on a silicon micro-electro-mechanical systems (MEMS) biochip. The system will allow clinical diagnostics laboratories faster, cheaper, and more user-friendly access to genomic-based techniques for infectious disease detection.
STMicroelectronics has made a joint development agreement with MobiDiag to create a complete system for genomic-based detection of infectious diseases based on a silicon micro-electro-mechanical systems (MEMS) biochip. The system will allow clinical diagnostics laboratories faster, cheaper, and more user-friendly access to genomic-based techniques for infectious disease detection.


In October 2002, ST announced the development of a disposable, standalone device that performs DNA amplification and detection of target DNA sequences. The Polymerase Chain Reaction (PCR) technique performed on the device is implemented using a silicon MEMS chip in which channels buried in the silicon carry the mixture of sample and reagents while highly accurate resistive heating elements perform the temperature cycling. Using this device, the PCR technique can be applied in a compact analysis tool that only requires very small quantities of the costly reagents. Disposable cartridges will ensure ease of use and greatly reduce the risk of cross-contamination of samples.


Currently, conventional laboratories perform DNA analysis with large and costly equipment that can take several hours to use. Consequently, physicians must frequently prescribe antibiotics or antivirals prior to determining the exact pathogen causing an infection. The ST/MobiDiag solution will reduce the cost and complexity of the diagnosis by producing consumables that will be very competitive and offer superior performance compared to existing solutions. The companies hope that this will help reduce improper treatment with antibiotics, the overuse of which has resulted in increasing antibiotic-resistant strains of bacteria and the decreasing effectiveness of many commonly prescribed antibiotics.


Ugo Carena, vice-president for the Computer Peripherals and Industrial group of ST, comments: "This alliance joins two of the key competencies needed to develop a marketable biochip product; the micro-fluidics technology from ST, and the molecular microbiology expertise from MobiDiag. Their unique understanding of infectious disease diagnostics and of our target market makes them the ideal partner to generate a complete system. With this partnership we believe we carry the entire spectrum of knowledge needed to detect key diseases and produce a marketable product."


Jaakko Pellosniemi, CEO of MobiDiag, adds: "By integrating ST's silicon expertise with our diagnostic assays, a doctor will have the ability to conduct simultaneous detection of large panels of different pathogens that represent distinct groups of related infections."



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